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Health care interventions and products need to be thoroughly evaluated. Their potential benefits, harms, and added value for consumers, patients and health care systems need to be described and analyzed.

ceb is providing strategic insightful solutions to customers to realize their projects and to improve tomorrow's patient outcomes.

For further information please contact:

Prof. Heiner C. Bucher, MD MPH
Head of Institute

Phone +41 61 556 5100

Evidence synthesis

Systematic reviews and meta-analyses are a crucial element in informed decision making and have a pivotal role in health technology assessments and clinical guideline development. They are equally important for the development of modern drugs, medical tests and devices. The institute has been commissioned to prepare systematic reviews and to support development of evidence-based treatment guidelines for governmental decision making bodies, publicly funded organizations, health insurers, medical associations and pharmaceutical companies.

Further information can be found in our publications and project descriptions.

Health technology assessment

ceb is an independent academic institution specialized in health technology assessments. In close collaboration with associated health economists, ethicists and lawyers we provide decision makers with reliable knowledge on clinical and cost effectiveness, and if needed relevant ethical and legal issues of health care interventions. We are working for different commissioners like the Swiss Federal Office of Public Health (SFOPH), the Swiss Medical Board (SMB), the German Institute for Quality and Efficiency in Health Care (IQWiG) and as a sub-contractor for the National Institute for Health and Care Excellence (NICE) in the UK. Commissioned by the SFOPH we have been involved in EUnetHTA projects since the first EUnetHTA Joint Action.


Full and Rapid HTA reports, preparation of submission documents

ceb is providing full and rapid HTA reports depending on the needs and requirements of health technology agencies and we can offer support in the submission process.

Development of methods and processes in HTA

ceb provides consultancy services to several HTA agencies for the development of HTA methods and processes. Within the EUnetHTA project we have collaborated in the development of the Core Model for the evaluation of screening technologies and the development of guidance for the evaluation of the risk of bias in non-randomized intervention studies.

Further information can be found in our list of HTA projects and publications.

Real world evidence

There is a rising demand for high quality observational studies. Comparative effectiveness research is increasingly used to inform reimbursement decisions with the aim to enhance quality of care. This requires strategies beyond product licensing studies such as the continuous assessment of benefits and harms after product approval. Important steps in this evaluation process are the actively planned comparison of the effectiveness of different interventions or products and the mitigation of risks. With its longstanding experience ceb has the knowledge to bridge the gap from product approval to long-term product success.


Observational data analysis

ceb has long-standing expertise in creating and analyzing real world evidence. We use advanced technologies that aim to minimize bias from observational study analyses. We use findings from our empirical and methodological research to inform our methods for analyzing observational data. Our clients are mainly from the pharmaceutical industry.

Routinely collected data analysis

We are experienced in the analysis of large nationwide registry data and conduct of pharmacoepidemiological studies, looking at patient important clinical outcomes, safety data, or cost-impact in health economic studies. More recently we began to use routinely collected data to design comparative and pragmatic trials for the nationwide evaluation of health care interventions in routine practice, maximizing both internal and external validity.

Further information can be found in our publications.

Consultancy for scientific projects

As an academic institution we are experienced in advising investigators and clients on scientific projects from planning the protocol and submission to data analysis and publication.. We provide and coordinate our services in collaboration with our partners of the Clinical Trial Unit (CTU) within the Department of Clinical Research of the University Hospital Basel.


ceb has expertise and provides consultancy services on:

  • Study planning and design
  • Protocol development
  • Research reporting and manuscript development
  • Systematic literature reviews and meta-analysis
  • Pharmacoepidemiological analysis with use of registry data
  • Observational data and clinical trial analysis
  • Pharmacoeconomic modeling and analysis
  • Reporting continues along international guidelines(e.g. SPIRIT, CONSORT, PRISMA, RECORD)


Systematic literature reviews

ceb has extensive experience in providing support for all the steps in evidence synthesis, from the planning phase including scoping, synthesizing the findings to the creation and delivery of reports tailored to the needs of clients.


ceb has published more than 100 meta-analyses of drugs, medical tests, devices and studies of complex interventions. Our methods include direct or indirect comparisons, network meta-analyses, individual patient data meta-analyses, and methods to evaluate test accuracy.

Indirect comparisons and network meta-analysis

We use network meta-analysis of trials involving treatments compared directly, indirectly, or both. Our long-standing expertise started with the development of the first indirect comparison method (Bucher method).

Individual patient data meta-analysis (IPD)

ceb is experienced in IPD, aiming at the exploration of treatment effects in different patient groups, individual treatment responses and the impact of particular risk factors.

Further information can be found in our publications.

Clinical guideline development

ceb is experienced in the support of clinical guideline groups including the World Health Organization as well as German guideline groups and the IQWiG. Members of our team are involved in the GRADE network and have substantial expertise in this field.


Evidence generation and methods

ceb caters to the special needs of clinical guideline groups and offers methodological support tailored to requirements of groups that often use different tools for the evaluation of the quality of the evidence. We contributed as external experts to an IQWiG project on the evaluation of criteria for the evaluation of the internal validity of clinical guidelines.

Further information can be found in our list of projects