Our projects

Learning from failure - Understanding the mechanisms of trial discontinuation DISCO 2

In a first project we will conduct semi-structured interviews with principal investigators of RCTs discontinued for insufficient recruitment and with key stakeholders of clinical research in Switzerla...

Status: ongoing Duration: Dec 2013 - Dec 2020

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Adjunctive corticosteroids for Pneumocystis jiroveci pneumonia in patients with HIV-infection

We will update our Cochrane Review on adjunctive corticosteroids for Pneumocystis jiroveci pneumonia in patients with HIV-infection.

Status: completed Duration: Sep 2010 - Mar 2015

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Anästhesie - PIEB

This retrospective cohort study aims at investigating the effects of Programmed intermittent epidural bolus (PIEB) combined with patient- controlled epidural bolus (PCEA) on maternal motor function an...

Status: completed Duration: Feb 2015 - Mar 2019

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Antivirals for influenza like syndrome: A randomised controlled trial of clinical and cost effectiveness in primary care

Influenza is a highly contagious infection with considerable morbidity, mortality in particular in the elderly and economic implications. Therefore individuals at high risk from influenza related comp...

Status: completed Duration: Oct 2015 - Sep 2018

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ART-CC Single Tablet

Most patients with HIV start antiretroviral therapy on a single tablet once a day regimen. However it is not clear whether single tablet regimens actually lead to better clinical outcomes. The best wa...

Status: completed Duration: Apr 2014 - Oct 2017

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Carbetocin Study: Carbetocin - Appropriate Rate Better Equilibrium between Tonus and Circulation

Carbetocin is routinely given during the caesarean section to improve the uterine contraction with the aim of reducing the blood loss. In this randomised, controlled double-blind non-inferiority trial...

Status: completed Duration: Jan 2012 - Dec 2016

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CEIT - Cancer (Comparative Effectiveness of Innovative Treatments for Cancer)

Timely access to innovative treatments is paramount for patients with cancer. However, by applying flexibility to the approval pathways, substantial uncertainty in clinical decision-making is created,...

Status: completed Duration: Oct 2015 - Jan 2018

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Chronic hepatitis B and C co-infection and risk for the development of Non-Hodgkin lymphoma in HIV-infected patients: A multinational cohort study

Despite the success of modern antiretroviral therapy Non-Hodgkin Lymphoma (NHL) continues to be an important cause of AIDS and AIDS related mortality in HIV-infected individuals. Hepatitis C (HCV) and...

Status: completed Duration: Jun 2013 - Oct 2016

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Comparative treatment effects of on-label and off-label drug use: meta-epidemiological study

Off-label use of a drug refers to any application that is in deviation from the use approved by a drug licensing agency. Preferably off-label drug use should be considered when there is no alternative...

Status: completed Duration: Dec 2013 - Oct 2016

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Concordance of treatment effects of \"real world\" observational studies using marginal structural models and randomized controlled trials: meta-epidemiological study

Marginal structural models (MSMs) are increasingly used to address confounding issues in biomedical reserarch. This meta-epidemiological study seeks to explore whether modern MSM-based analyses of ‘...

Status: completed Duration: Mar 2013 - Dec 2016

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COpeptin – a Biomarker to Assess the Severity of PAncreatitis (COPA-Study)

The aim of this study is to assess whether in patients with acute pancreatitis (AP) copeptin, pro-atrial natriuretic peptide (pro-ANP), pro-adrenomedullin (pro-ADM) and cortisol are associated with di...

Status: completed Duration: Apr 2010 - Sep 2016

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Defining “Quality” in Clinical Research – A systematic review and structured framework

The objectives of this study are 1) to systematically review suggested definitions for “quality” in the context of clinical research taking into consideration the viewpoints of different stakehold...

Status: completed Duration: Oct 2014 - Oct 2018

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Development and validation of an instrument to assess the credibility of putative subgroup effects in randomized controlled trials and meta-analyses

The overall goal of this project is to provide clinicians, researchers, and decision-makers with a reliable, valid, and functional instrument for assessing the credibility of subgroup effects found in...

Status: completed Duration: Nov 2013 - Jul 2020

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Development of the QUADAS 2 tool (Quality Assessment of studies of Diagnostic Accuracy in Systematic reviews)

The QUADAS instrument was developped to assess the methodological quality of studies on the accuracy of diagnostic tests. The aim of the project is to improve the current QUADAS instrument.

Status: completed Duration: May 2010 - Jun 2012

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DISCO - design features DISCO 2

This study is a matched comparison between discontinued RCTs and completed RCTs. Based on key characteristics of the trials discontinued due to poor recruitment (i.e. patient population, intervention,...

Status: completed Duration: Feb 2014 - Dec 2019

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DISCO - Pediatrics DISCO 1

The objective of this study is to determine the prevalence of, and reasons for, discontinuation of RCTs in Pediatrics. We will further explore the publication history of pediatric trials and the quali...

Status: completed Duration: Mar 2014 - May 2016

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DISCO - Randomised versus non-randomised discontinued studies, DISCO 1

The objective of this study is to compare the prevalence and reasons for discontinuations between randomized controlled trials and non-randomized studies.We will do this based on a retrospective cohor...

Status: completed Duration: Aug 2013 - Sep 2016

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DISCO - Registered discontinued RCTs DISCO 2

The objective of this project is to examine the comprehensiveness and reliability of the registry information on discontinued trials in order to assess its usefulness. In order to achiev this we will ...

Status: completed Duration: Jan 2014 - Oct 2016

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DISCO - Reporting of discontinued trials DISCO 2

The objectives of this empirical study are (i) to gather a comprehensive list of published root causes for RCT discontinuation due to poor recruitment, (ii) to examine to what extent and how investiga...

Status: completed Duration: Jan 2013 - Jul 2016

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Disregarding paired and clustered data in surgical research - evaluation of the current practice and estimation of implications on study results

Multiple surgical procedures in a single patient are relatively common and lead to dependent (clustered) data. This dependency needs to be accounted for in study design and data analysis. A systematic...

Status: completed Duration: Feb 2013 - Jan 2018

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Effects of the Swiss human research legislation on the costs of RCTs

The objectives of this study are to compile a comprehensive list of cost items for the planning and conduct of RCTs (industry and academic settings), to determine the unit costs for listed cost items ...

Status: completed Duration: Jul 2015 - Dec 2017

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Efficacy and safety of low-dose corticosteroids in patients with community acquired pneumonia: Systematic review and individual patient-data meta-analysis of randomized trials

We will undertake a systematic review and IPD meta-analysis of all available RCTs to study the benefits and possible harms of using adjunctive low-dose corticosteroids in the treatment of patients wit...

Status: completed Duration: Feb 2015 - Sep 2016

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Fibrates for the primary prevention of cardiovascular disease.

Fibrates for the primary prevention of cardiovascular disease.

Status: completed Duration: Jan 2016 - Oct 2016

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Functional results after chest wall stabilization with a new screwless fixation device

The aim of this study is to describe the experience in two surgical centres with a new screwless fixation device for the management of two types of rib fractures: flail chest and multiple dislocated r...

Status: completed Duration: Sep 2011 - Dec 2014

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HIV and non-HIV related morbidity and its associated resource use and costs in the Swiss HIV Cohort Study (SHCS): A data linkage pilot study

There exists little data on costs and resource use for inhospital and ambulatory care and its main drivers in individuals with HIV infection in Switzerland. In this project of the Swiss HIV Cohort Stu...

Status: completed Duration: Oct 2014 - May 2018

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How to write a surgical clinical research protocol: literature review and practical guide

Clinical research in studies involving surgical interventions presents some specific challenges. On the basis of a literature search of methodological literature and on some cardinal published surgica...

Status: completed Duration: Jul 2012 - Jan 2014

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Impact of non-standardized outcome analyses on clinical care of HIV patients: meta-epidemiological study

HIV-infection is treated with highly effective antiretroviral treatment (ART). Healthcare decision makers deem suppression of HIV RNA below a certain blood level highly relevant marker of therapeutic ...

Status: completed Duration: Feb 2016 - Jan 2017

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Investigation of continuous effect modifiers in a meta-analysis on higher versus lower positive end-expiratory pressure (PEEP) in ventilated patients with acute respiratory distress syndrome (ARDS)

We will use the multivariable fractional polymonia interaction (MFPI) approach to investigate the interaction between continous patient baseline characteristics (body mass index, Pa02/Fi02, respirator...

Status: completed Duration: Jun 2010 - Jul 2016

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Kurs Versicherungsmedizin

No project description yet

Status: completed Duration: Aug 2020 - Aug 2020

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Longitudinal evaluation of the accuracy and completeness of clinical trial protocols - evidence for improvement?

The Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) were published in 2013 and the new Swiss federal Law on Research in Humans (Humanforschungsgesetz, HFG) came into effect...

Status: completed Duration: Nov 2014 - Jul 2020

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Personalized prescription feedback to reduce antibiotic overuse in primary care: nationwide pragmatic randomized controlled trial

Excessive usage of antibiotics raise the emergence of resistant bacterias which poses an increasingly serious problem in Europe. The aim of this randomised controlled trial is to evaluate the effect o...

Status: completed Duration: Jan 2011 - Dec 2016

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Pragmatic randomized trials using routinely collected health data: meta-epidemiological study

Many highly important healthcare questions are poorly addressed by randomized controlled trials (RCTs). Often RCTs are too short and/or too small to evaluate patient-relevant outcomes (such as mortali...

Status: completed Duration: Feb 2016 - Jan 2017

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REporting of studies Conducted using Observational Routinely-collected Data (RECORD): a systematic review

This project seeks to evaluate if the results of studies of routinely collected health data (e.g. from electronic health records, administrative claims, or patient registries) are adequately reported ...

Status: completed Duration: Jan 2013 - Jun 2016

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Risk of non-AIDS defining and AIDS defining malignancies with early versus delayed initiation of antiretroviral therapy: an international multicohort study

The objective of this study is to investigate the relationship between delayed versus early initiation of antiretroviral therapy (ART) and the risks of non-AIDS defining (NADM) and AIDS defining malig...

Status: completed Duration: Jul 2017 - Dec 2019

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SHCS 761 Physical activity in HIV patients over time

The prevalence of cardiovascular risk factors is high in patients infected with HIV. While there is growing evidence that physical activity is safe and effective in improving cardiorespiratory fitness...

Status: completed Duration: Sep 2014 - Sep 2016

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SHCS 805 Drug-in Drug Interactions

Potential drug-drug interactions (DDI) are the most common drug-related problem in ambulatory care and a growing problem in HIV infection due to increasing comorbidities and age of HIV-infected patien...

Status: completed Duration: Oct 2016 - Dec 2018

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Smartphone app and CO selfmonitoring for smoking cessation: A randomised controlled trial nested into the Swiss HIV Cohort Study

This a randomized controlled trial nested in the Swiss HIV cohort comparing the effectiveness of a martphone app and carbon monoxide self-monitoring support for smoking cessation. The primary outcome ...

Status: completed Duration: Aug 2016 - Dec 2019

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Stopped trials early for benefit – trials published after a stopped trial – ethical? (STOP-IT 3)

The study investigates how often randomised trials (RCTs) are launched or completed after the publication of a trial stopped early for benefit addressing the same question. RCTs are stopped early for ...

Status: completed Duration: Nov 2009 - Oct 2016

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Systematic reviews on lipid-modifying interventions

We will conduct and update several systematic reviews and meta-analyses investigating the benefit and adverse events of fibrates, ezetimibe, and niacin in primary and secondary prevention of cardiovas...

Status: completed Duration: Jan 2009 - Oct 2016

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Tenofovir in HIV-infected patients pretreated with anitretroviral therapy: A systematic review and meta-analysis of randomized controlled trials

We assess in a systematic review and meta-analysis the benefit and side effects of tenofovir in HIV infected adults and children who are pretreated with an antiretroviral therapy (ART) and newly init...

Status: completed Duration: Jan 2013 - Oct 2016

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The Mannitol Bronchial Challenge Test in the Diagnosis of Asthma

The objective of this systematic review and meta-analysis will be to assess the diagnostic accuracy of the mannitol bronchial provocation test for the diagnosis of asthma in adults by pooling sensitiv...

Status: completed Duration: Aug 2010 - Dec 2016

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Use of heparin for cancer: indivdual patient data meta-analysis

Study level systematic reviews on this topic indicate a reduction in venous thromboembolism and provide moderate confidence that a small survival benefit exists. We will perform an individual patient ...

Status: completed Duration: Apr 2013 - Jul 2020

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Utilisation and effectiveness of daclatasvir-based treatment regimes in chronic hepatitis C infection in Europe - real-world data from named patient programs in Europe

Daclatasvir (DCV) is a new, direct-acting antiviral agent for the treatment of chronic hepatitis C virus infection. It received marketing authorization from the European Medicines Agency in August 201...

Status: completed Duration: Apr 2015 - Sep 2016

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Variations and determinants of antibiotic use in adult outpatients: A representative analysis of claim records from the Swiss population

Antibiotic resistance is a major public health problem and related to the frequency of antibiotic prescriptions. Most antibiotics are prescribed in primary care. We investigate patterns of antibiotic ...

Status: completed Duration: Dec 2008 - Aug 2010

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