Heiner C. Bucher
Status: completed Duration: Oct 2015 - Sep 2018
Influenza is a highly contagious infection with considerable morbidity, mortality in particular in the elderly and economic implications. Therefore individuals at high risk from influenza related complications and health care staff should be annually vaccinated. Whether antiviral treatment of patients with flu-like syndroms during influenza seasons is beneficial remains controversal. In this large trial 4500 children and adults from 20 European networks will be randomized to oseltamivir, nitazoxanide (each for 5 days), or usual care. Outcomes of interest are return to normal daily activity and the cost-effectiveness of the interventions. The trial represents work package 4 of the Platform of European Preparedness against Reemerging Epidemics (PREPARE) and is funded by the EU, with CEB representing the Swiss network.