Status: completed Duration: Apr 2010 - Sep 2016
The aim of this study is to assess whether in patients with acute pancreatitis (AP) copeptin, pro-atrial natriuretic peptide (pro-ANP), pro-adrenomedullin (pro-ADM) and cortisol are associated with disease severity and to compare their prognostic accuracy when predicting organ failure or death. We include all consecutive patients with AP from April 2011 to January 2015 in this single center prospective study conducted at a tertiary referral center. Included patients are observed for four days after inclusion. Disease severity is assessed using the Atlanta 1992 and 2012 criteria and organ failure using the modified Marshall score. Copeptin, pro-ANP, pro-ADM and cortisol as well as the established markers C-reactive protein (CRP) and procalcitonin are measured.