Stefan Schandelmaier, Gordon Guyatt, Xin Sun, Matthias Briel
Status: ongoing Duration: Nov 2013 - Jul 2020
The overall goal of this project is to provide clinicians, researchers, and decision-makers with a reliable, valid, and functional instrument for assessing the credibility of subgroup effects found in randomized trials and meta-analyses. In a first step, we will conduct a systematic survey of the methodological literature addressing the conduct and interpretation of subgroup analyses. We will identify and summarize currently suggested credibility criteria and the rationale offered for these criteria, in the process generating a list of potential instrument items and evidence or opinion about the relative merits of the criteria.