Risk of non-AIDS defining and AIDS defining malignancies with early versus delayed initiation of antiretroviral therapy: an international multicohort study

Heiner C. Bucher and Giusi Moffa

Status: completed Duration: Jul 2017 - Dec 2018

The objective of this study is to investigate the relationship between delayed versus early initiation of antiretroviral therapy (ART) and the risks of non-AIDS defining (NADM) and AIDS defining malignancies (ADM). The analysis will be based on data from European cohorts including HIV infected individuals, and more specifically from the Data Collection o­n Adverse events of Anti-HIV Drugs (D:A:D) database, a prospective multi-cohort study of HIV-1 positive persons (https://chip.dk/Studies/DAD). The aim of our study is to compare and model different ART initiation strategies in relation to the risk of NADM, ADM and death using state of the art statistical methods to adjust for baseline and time-varying confounders.

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