Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

Nat Commun 2019; 10: 3193, ISBN 2041-1723 (Electronic)
2041-1723 (Linking) (Journal)

Bachmann N., von Siebenthal C., Vongrad V., Turk T., Neumann K., Beerenwinkel N., Bogojeska J., Fellay J., Roth V., Kok Y. L., Thorball C. W., Borghesi A., Parbhoo S., Wieser M., Boni J., Perreau M., Klimkait T., Yerly S., Battegay M., Rauch A., Hoffmann M., Bernasconi E., Cavassini M., Kouyos R. D., Gunthard H. F., Metzner K. J.

The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.

To the List of Publications