Forschungsbereiche

Unsere Forschungsbereiche

  • Wir untersuchen durch systematische Literaturaufarbeitung, Technologiebewertung und eigene Forschungsprojekte (randomisierte kontrollierte Studien und Beobachtungsstudien) den Nutzen und den Schaden von medizinischen Interventionen
  • Wir verbessern durch Methodikforschung die patienten-orientierte klinische Forschung, damit Patienten sowie Entscheidungsträger sich auf Forschungsergebnisse besser verlassen können
  • In nationalen und internationalen Beobachtungsstudien untersuchen wir die Prognose von Krankheiten sowie die Langzeitverträglichkeit von neuen Medikamenten bei Patienten im klinischen Alltag

Details zu Forschungsprojekten: Siehe unter Forschungsgruppen.

Wirksamkeitsforschung

Vergleichende Wirksamkeitsforschung (comparative effectiveness research) schafft Evidenz zum Nutzen und Schaden verschiedener diagnostischer und therapeutischer Massnahmen mit dem Ziel, die medizinische Entscheidungsfindung zu verbessern. Die Evidenz stammt aus randomisierten klinischen Studien, und pragmatischen Studien (pragmatic trials), sowie aus Beobachtungsstudien. Diese Evidenz kann in systematischen Übersichtsarbeiten und Meta-Analysen zusammengefasst werden. ceb besitzt das Methodikwissen zur Durchführung unterschiedlichster klinischer Studientypen.

Evidenzsynthese

Wir erstellen systematische Übersichtsarbeiten und Meta-Analysen in zahlreichen Gebieten der Medizin zur Untersuchung von Medikamenten, medizinischen Apparaten, Verfahren, diagnostischen Tests und komplexen Interventionen.

Hierzu verwenden wir verschiedene spezifische Methoden, direkte und indirekte Vergleiche (die vom Institutsleiter entwickelte Bucher Methode), Netzwerk-Meta-Analysen, aggregierte und individuelle Patientendaten-Meta-Analysen, sowie Meta-Analysen von diagnostischen Tests.

Datenanalysen von Beobachungsstudien

Wir arbeiten mit Daten verschiedener nationalen und internationalen Beobachtungsstudien, sowie mit Routinedaten und erforschen prognostische Faktoren sowie die Wirksamkeit und Langzeitsicherheit von Medikamenten. ceb hat langjährige Erfahrung mit der Analyse von Kohortenstudien, insbesondere im Bereich der HIV-Infektion. Das Datenzentrum der Schweizerischen Transplantationskohorten-Studie ist mit dem Institut assoziiert.


Pragmatic trials

Pragmatische Studien (Pragmatic trials) versuchen eine bestmögliche Anwendbarkeit der Studienergebnisse für Alltagsbedingungen zu erreichen. Wir führen pragmatische randomisierte kontrollierte Studien, welche auf routinemässig erhobenen Registerdaten beruhen oder in hochstandardisierte Kohortenstudien eingebaut werden. Dies ermöglicht uns, den Nutzen von Interventionen besser unter klinischen Alltagsbedingungen zu untersuchen, sowie die Sammlung von Daten rascher und effizienter zu gestalten.


Methodologische Forschung, Research on Research

Die Entwicklung und Verbesserung der Methodik angewandter patienten-orientierter Forschung ist einer von mehreren Schwerpunkten des ceb. Hierbei erforschen wir die Struktur der medizinischen Forschung (Research on Research) und versuchen systembezogene Verbesserungen zu erreichen.

  • ceb untersucht Gründe für einen vorzeitigen Abbruch von klinischen Studien. Wir erarbeiten Strategien zur Abbruchsvermeidung, damit klinische Fragestellungen schlüssig beantwortet und Forschungsmittel optimal eingesetzt werden.
  • Wir untersuchen, wie die Qualität und Aussagekraft von routinemässig erhobenen Daten und Analysen von Beobachtungsstudien verbessert und verlässliche Information zur Qualität der Versorgung und Langzeitsicherheit von Interventionen gewonnen werden können.
  • ceb engagiert sich in Initiativen zur Verbesserung der Qualität von wissenschaftlichen Forschungsberichten um Forschungsmittel effizienter einzusetzen und wissenschaftliche Erkenntnisse optimal zu nutzen.
  • Wir setzen uns für die Schaffung von evidenz-basierten Standards und für eine transparente klinische Forschung ein, welche die Reproduzierbarkeit von klinischen Forschungsergebnissen sowie die Verschwendung von Forschungsressourcen durch fehlende Standardisierung vermeiden soll.


Forschungsgruppen

Forschungsgruppe Prof. Dr. med. Heiner C. Bucher MPH

Prof. Dr. med. Heiner C. Bucher, MPH

Position(s) Director of Institute, Attending Division of Infectious Diseases & Hospital Hygiene Lecturer ETH Zurich, Health Sciences & Technologies

Institution University Hospital Basel

Phone +41 61 328 61 01

Email heiner.bucher@usb.ch

Name Funktion Arbeitsbereich
Prof. Dr. med. Heiner C. Bucher, MPH Leitung Institutsleitung

📷 Research Focus

  • long-term effects and side effects of antiretroviral therapy
  • evidence-based decision making for antibiotic use

🔖 Curriculum Vitae

  • 2001 to present: Professor of Clinical Epidemiology, University of Basel, Director of the Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Switzerland
  • 1991 - 1994 & 1996 - 2001: Senior registrar, Internal Medicine Outpatient Clinics, University Hospital Basel, Switzerland
  • 1994 - 1996: Visiting professor Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
  • 1990 - 1991: Institute of Social and Preventive Medicine, University of Zurich, Switzerland
  • 1988 - 1990: School of Public Health, University of California, Berkeley, USA
  • 1984 - 1988: Internships Internal Medicine Ospedale San Giovanni Bellinzona and University Hospital Basel, Switzerland
  • 1983 - 1984: Research Fellow, University of Basel and Institute Universitaire de Médecine Sociale et Préventive Lausanne, Switzerland
  • 1975 - 1983: School of Medicine, University of Basel, Switzerland
James Young, PhD Senior Biostatistician Biostatistik

📷 Research Focus

  • Bayesian analytic methods for observational data

🔖 Curriculum Vitae

  • 2001 to present: Senior biostatistican, Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Switzerland
  • 2009 to present: Honorary senior research fellow, Department of Public Health and General Practice, University of Otago, New Zealand
  • 2003 - 2007: Statistical advisor, Swiss Medical Weekly, Basel, Switzerland
  • 2000 - 2001: Statistician, Biometrical Practice BIOP AG, Basel, Switzerland
  • 1994 - 2000: Lecturer in statistics, Lincoln University, Christchurch, New Zealand
  • 1991 - 1994: Mathematical statistician, Statistics New Zealand, Christchurch, New Zealand
Prof. Dr. med. Alain Nordmann, MSc Associated Researcher Klinische Epidemiologie

📷 Research Focus

  • Cardiovascular medicine
  • Primary care
  • Health economics

🔖 Curriculum Vitae

  • 2005 to present: Assistant professor, Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Switzerland
  • 2002 - 2005: Senior researcher, Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Switzerland
  • 2001 to present: Private practice in Internal Medicine in Basel, Switzerland
  • 1999 - 2001: Masters of Science in Clinical Epidemiology and fellowship in Internal Medicine University of Toronto, Canada
  • 1993 - 1999: Internships and residency in Internal Medicine Felix-Platter Spital Basel, University Hospital Bern, St. Clara Spital Basel and University Hospital Basel, Switzerland
  • 1986 - 1992: School of Medicine, University of Basel, Switzerland
Soheila Aghlmandi, PhD Senior Biostatistician Biostatistik

📷 Research Focus

  • Computational methods in medical research with focus on prognostic research
  • Bayesian approaches for quantitative evidence Synthesis

🔖 Curriculum Vitae

  • June 2019 - present: Senior Biostatistician, Basel Institute of Clinical Epidemiology and Biostatistics
  • April 2017 - May 2019: Biostatistician, Basel Institute of Clinical Epidemiology and Biostatistics
  • May 2014 - March 2017: Biostatistician, Clinical Trial Unit of the University of Bern
  • Nov 2012 - March 2017: PhD Biostatistics, Institute of Social and Preventive Medicine, University of Bern
  • Nov 2012 - April 2016: Early stage researcher, MEDIASRES, Marie Curie Initial Training network
Frédérique Chammartin MSc, PhD Biostatistician Biostatistik

📷 Research Focus

  • Computational methods in medical research with focus on epidemiological studies and prognostic research
  • Bayesian spatio-temporal modelling


🔖 Curriculum Vitae

  • September 2019 - present: Biostatistician, Basel Institute of Clinical Epidemiology and Biostatistics
  • 2016 - 2019: Biostatistician, Institute of Social and preventive Medicine, Bern, Switzerland
  • 2014 - 2016: Scientific collaborator, Swiss Tropical and Public Health Institute, Bayesian Modelling and Analysis unit, Basel, Switzerland
  • 2011 - 2014: PhD fellow in Epidemiology within the Bayesian Modelling and Analysis unit, Swiss Tropical and Public Health Institute, Basel, Switzerland
  • 2008- 2010: Master of Science in Statistics, University of Neuchâtel, Switzerland
  • 2002- 2007: Pharmacist at different locations
  • 1996-2001: Diploma Federal in Pharmacy, University of Fribourg and Lausanne, Switzerland
Florian Samuel Halbeisen, PhD Biostatistician Biostatistik

📷 Research Focus

Computational methods in medical research with focus on epidemiological studies and prognostic research

🔖 Curriculum Vitae

2019 to present: Biostatistician for Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Switzerland

2015-2019: PhD in Health science, Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland

2014- 2016: Diploma in Applied Statistics, University of Bern, Switzerland

2011- 2014: Master of Science in Animal Biology, University of Basel, Switzerland

2007- 2011: Bachelor of Science in Biology, University of Basel, Switzerland

Anshoo Nadella Biostatistician Biostatistik

📷 Research Focus

Computational methods in medical research with focus on epidemiological studies

🔖 Curriculum Vitae

February 2021 to present: Junior Biostatistician at Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Switzerland

Oct2019- Mar2020: Domain Expert Consultant at Roche, Germany

Dec2018- Aug2019: Certificate of Advanced Clinical trials at University Hospital Basel, Switzerland

Sep2015- July2017: Masters of Public Health Specializing in Epidemiology, University of EHESP, Paris, France

2008- 2013: Clinical Dental Practice, India

Eric Remera, MSc. PhD Student Epidemiology Klinische Epidemiologie

📷 Research Focus

RESEARCH FOCUS

  • Longitudinal data analysis
  • Policy Evaluation using statistical methods
  • Bayesian statistics and Decision Models

🔖 Curriculum Vitae

Curricurum Vitae

  • 2018 to present: PhD student in Epidemiology, University Hospital, Basel Clinical Epidemiology and Biostatistics and Swiss Tropical and Public Health Institute, University of Basel, Switzerland

  • 2018 to present: Visiting Lecturer, University of Global Health Equity, Kigali- Rwanda

  • 2013 to present: Director of HIV Surveillance and research unit, Institute of HIV Disease Prevention and Control, Rwanda Biomedical Center.

  • 2012-2013: Head of HIV Biostatistics, Institute of HIV Disease Prevention and Control, Rwanda Biomedical Center.

  • 2010-2012: Data analyst, Future Group international supporting HIV Care and Treatment Department, Treatment and Research Center for AIDS (TRAC), Kigali, Rwanda
Dr. med. Jan Adam Roth Associated Researcher Klinische Epidemiologie

📷 Research Focus

Digital epidemiology

— Multidisciplinary research using routine (healthcare) data sources

— Machine learning and large-scale analysis techniques

— Applications in preventive medicine and infectious diseases

🔖 Curriculum Vitae

Since 10/2020 Research associate; Division of Research & Analytical Services, Department of Informatics, University Hospital Basel

Since 08/2020 Associated researcher; Basel Institute for Clinical Epidemiology & Biostatistics (ceb)

Since 08/2020 Attending; Division of Infectious Diseases & Hospital Epidemiology, University Hospital Basel

Since 04/2020 Independent epidemiological consultant

Since 03/2020 Academic editor for epidemiology, biostatistics and infectious diseases, Swiss Medical Weekly


07/2018 to 07/2020: Research associate

Part of a specialist training platform in prevention and epidemiology in association with the Swiss Tropical and Public Health Institute at:

  • Division of Infectious Diseases & Hospital Epidemiology, University Hospital Basel
  • Basel Institute for Clinical Epidemiology and Biostatistics
  • Swiss National Center for Infection Prevention (Swissnoso)

10/2017 to 10/2020: MSc student in epidemiology; London School of Hygiene & Tropical Medicine, University of London

2017-06/2018: Research associate; Division of Infectious Diseases & Hospital Epidemiology, University Hospital Basel

2016: Resident clinical IT; Department of Internal Medicine, University Hospital Basel

2014-2015: Resident and MD student; Medical University Clinic Liestal, and Division of Infectious Diseases & Hospital Epidemiology, University Hospital Basel 2008-2013: Studies of medicine; University of Basel, University of Oxford, and Jia Tong University Shanghai

Dr. med. Sabin Nsanzimana, MSc Associated Researcher Klinische Epidemiologie

📷 Research Focus

  • Improving linkage and retention in entire Rwanda National HIV program using routinely collected data.
  • Long term HIV treatment outcomes in general and key populations
  • Viral Hepatitis implementation science in resource limited settings

🔖 Curriculum Vitae

  • 2015 to present: PhD in Epidemiology, University Hospital, Basel Clinical Epidemiology and Biostatistics and Swiss Tropical and Public Health Institute, University of Basel, Switzerland
  • 2012 to present: Global Health Delivery faculty, University of Global Health Equity, Kigali
  • 2009 to present: Director of Rwanda National HIV program and Division Manager for HIV/AIDS and Viral Hepatitis and the Institute of HIV Disease Prevention and Control, Rwanda Biomedical Centre
  • 2007 - 2009: Director, HIV Care and treatment department, Treatment and Research for AIDS Center (TRAC), Kigali, Rwanda
Prof. Dr. med. Dr. med. dent. Pedram Sendi, PhD Associated Researcher Gesundheitsökonomie

📷 Research Focus

  • Economic evaluations of health care interventions, methodological issues in cost-effectiveness analysis, probabilistic modeling, quality of life research, budget impact analysis
  • Evidence-based medicine and dentistry

🔖 Curriculum Vitae

  • 2006 to present associated senior researcher Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel
  • 2002 - 2006: Senior researcher, Basel Institute for Clinical Epidemiology Biostatistics & Division of Infectious Diseases, Department of Internal Medicine, Medical Faculty, University of Basel, Basel, Switzerland
  • 2000 - 2002: Visiting Research Fellow, Institute for Medical Technology Assessment, Erasmus University, Rotterdam, The Netherlands
  • 1999 - 2000: Visiting Research Fellow, Center for Health Economics and Policy Analysis, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
  • 1996 - 1999: Research Fellow, Basel Center for HIV-Research, Outpatient Department of Internal Medicine, Basel University Hospital, and Institute for Medical Informatics and Biostatistics, Riehen/Basel, Switzerland
  • 1989 - 1995 School of Medicine, University of Basel, Switzerland
Prof. Dr. med. Laurent Audigé Associated Researcher Klinische Epidemiologie

📷 Research Focus

Planning and implementation of clinical registers and studies in orthopedics

Applied methodological research (classifications, complications, outcome instruments, evidence- based medicine, systematic literature reviews, cost-effectiveness evaluations)

🔖 Curriculum Vitae

Employment history

2012-current Senior Research Fellow -

Head of Research Team Upper Extremity and Hand Surgery; Schulthess Clinic, Research and Development Department, Zurich, Switzerland

Affiliated Scientific Collaborator, University Hospital Basel, Basel, Switzerland Department of Orthopaedic Surgery and Traumatology (Prof. Dr. M. Jakob & PD Dr A.M. Müller) & Institute of Clinical Epidemiology and Biostatistics (Prof. Dr. H. Bucher)

Education

  • 2018 Titular Professor (epidemiology), Medical Faculty, University of Basel, Switzerland
  • 2002 Habilitation (epidemiology), Veterinary Faculty, University of Berne, Switzerland
  • 1995 PhD Degree, Dept. of Veterinary Clinical Sciences, Massey University, New Zealand
  • Supervisors: Prof. Peter Wilson & Prof. Roger Morris
  • 1988 Doctoral thesis, Doctorate of Veterinary Medicine, University of Créteil, France (award)
  • 1986 Veterinary degree, National Veterinary School of Maisons-Alfort, France (DVM)
Diana Grauwiler Clinical Research Manager Administration

Area of Research

Advanced Observational Data Analyses (Infectious diseases, HIV infection, chronic hepatitis C), Clinical Research Methodology, Real Word Evidence, Pragmatic Trials based on routinely collected data, Platform trials, Antibiotic stewardship, Health Technology Assessment (HTA), Meta-analysis.

Collaborations

National Collaborations

International Collaborations

Forschungsgruppe Prof. Dr. Matthias Briel

Prof. Dr. med. Matthias Briel, MSc FMH

Position(s) Senior Physician Clin Epi, Dep. of Clinical Resarch Deputy Director, Basel Institute for Clinical Epidemiology & Biostatistics Assistant Professor (pt), McMaster University, Hamilton, Canada

Institution University Hospital Basel

Phone +41 61 328 50 92

Email Matthias.briel@usb.ch

Name Funktion Arbeitsbereich
Prof. Dr. med. Matthias Briel, MSc Leitung Klinische Epidemiologie

📷 Research Focus

  • Clinical trial methodology
  • Systematic reviews and meta-analyses
  • Evidence-based clinical practice

🔖 Curriculum Vitae

  • 2011 to present: Assistant professor, Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Switzerland
  • 2009 to present: Senior Scientist, Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Switzerland, and Assistant Professor (part-time), Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada
  • 2006 - 2009: Research fellow & MSc student, Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada
  • 2003 - 2006: Research fellow, Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Switzerland
  • 2000 - 2003: Internships in Diagnostic Radiology, Neurology, and Intensive Care, University Hospital Freiburg, Germany
  • 1992 - 1999: Medical School, Albert-Ludwigs University, Freiburg, Germany
Dr. med. Dmitry Gryaznov, MSc Research Fellow Klinische Epidemiologie

📷 Research Focus

  • Clinical trial methodology

🔖 Curriculum Vitae

  • 2017 to present: PhD in Epidemiology, University of Basel, Switzerland
  • 2015 - 2017: Master of Science in Epidemiology, University of Basel, Switzerland
  • 2010 - 2012: PhD student, subdepartment of 'Emergency States in the Clinic of Internal Diseases', I.M. Sechenov First Moscow State Medical University, Moscow, Russia
  • 2008 - 2010: Residency in internal diseases, subdepartment of 'Emergency States in the Clinic of Internal Diseases', I.M. Sechenov First Moscow State Medical University, Moscow, Russia
  • 2002 - 2008: Degree in General Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russia
Dr. Sc. Viktoria Gloy Research Fellow Klinische Epidemiologie

📷 Research Focus

  • Health Technology Assessment (HTA)
  • Systematic reviews and meta-analyses
  • Clinical trial methodology

🔖 Curriculum Vitae

  • 2013 to present: Research Associate, Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Switzerland
  • 2011 - 2013: Junior Researcher, Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Switzerland
  • 2007 - 2011: Doctoral student, Swiss Federal Institute of Technology (ETH) Zurich, Switzerland, Institute of Food, Nutrition and Health, Physiology and Behaviour Laboratory
  • 2004 - 2007: Master of Science, Christian-Albrechts-University of Kiel, Germany, Nutrition and Food Science, "Oecotrophologie"
  • 2001 - 2004: Bachelor of Science, Christian-Albrechts-University of Kiel, Germany, Nutrition and Food Science, "Oecotrophologie"
Dr. med. Dr. phil. Stefan Schandelmaier Research Fellow Klinische Epidemiologie

📷 Research Focus

· Practice guidelines for health research methods

🔖 Curriculum Vitae

· 2019-present: Assistant Professor (part-time), McMaster University, Canada

· 2019-present: Scientist, Basel Institute for Clinical Epidemiology and Biostatistics

· 2019: PhD in Health Research Methods, McMaster University, Canada

· 2016-2019: Post-doc, Department of Health Research Methods, Evidence & Impact, McMaster University, Canada

· 2013-2016, Post-doc, Basel Institute for Clinical Epidemiology and Biostatistics

· 2010-2013 Research fellow, Evidence-Based Insurance Medicine, University of Basel

· 2011 Doctor of Medicine (Dr. med), University of Freiburg

· 2009 Staatsexamen (MD), Medical School, University of Freiburg

· 2008 Master in Music, University of Music, Freiburg

Dr. sc. med. Stuart McLennan Research Fellow Klinische Epidemiologie

📷 Research Focus

- Biomedical ethics

- Health policy analysis

- Patient safety and quality improvement

🔖 Curriculum Vitae

2019-present: Senior Research Associate, Institute of History and Ethics in Medicine, Technical University of Munich, Germany

2020-2021: Research Associate, Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Switzerland

2017-2019: Postdoctoral Research Fellow, Institute for Biomedical Ethics, University of Basel, Switzerland

2015-2017: Postdoctoral Research Fellow, Institute for History, Ethics and Philosophy in Medicine, Hannover Medical

2014-2015: Research Fellow, Centre for Health Policy, University of Melbourne, Australia

2011-2014: PhD in Biomedical Ethics, University of Basel

2010-2011: Research Assistant, Section for Social Policy and Social Economics and the Institute for Medical Ethics and History of Medicine, Ruhr-Universität Bochum, Germany

2008-2009: Complaints Assessor, Office of the Health and Disability Commissioner, Auckland, New Zealand

2006-2008: Master of Bioethics and Health Law, University of Otago, New Zealand

Benjamin Speich, PhD Research Fellow Klinische Epidemiologie

📷 Research Focus

  • Clinical trial methodology
  • Systematic reviews and meta-analyses

🔖 Curriculum Vitae

  • 2016 to present: Clinical Epidemiology & Biostatistics, University Hospital Basel, Switzerland
  • 2015 to present: Scientific Associate/Datamanager: Surgical Department, Cantonal Hospital Baselland, Switzerland
  • 2011 - 2014: PhD in Epidemiology Swiss Tropical and Public Health Institute, University of Basel, Switzerland
  • 2008 - 2010: Master of Science in Infection Biology and Epidemiology, Swiss Tropical and Public Health Institute, University of Basel, Switzerland
  • 2005 - 2008: Bachelor of Science in Biology, University of Basel, Switzerland
Ala Taji Heravi PhD Student Epidemiology Klinische Epidemiologie

📷 Research Focus

Clinical trial methodology

🔖 Curriculum Vitae

Jan 2020-Present: Research Assistant, Basel Institute for Clinical Epidemiology and Statistics, Switzerland.

May 2019 – 2020: Research Assistant at School of Social Work, University of Applied Sciences and Arts Northwestern, Basel, Switzerland

2018 – Present: Master Student in Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland

2016 – 2018: Statistical Analyst, Amar Negar Shargh Co. Mashhad, Iran

2014- 2018: Research Assistant, Department of Biostatistics and Epidemiology, Mashhad University of Medical Sciences, Mashhad, Iran

Alexandra Griessbach PhD Student Epidemiology Klinische Epidemiologie

📷 Research Focus

Clinical trial methodology

🔖 Curriculum Vitae

Nov 2020-Present: PhD student, Basel Institute for Clinical Epidemiology and Statistics, Switzerland.

Mar 2020-Nov 2020: Research assistant at Data Management, Communications and Research Ward Department, Clinical Trials Center Zurich, University Hospital Zurich (USZ), Switzerland.

Feb 2019-March 2020: Master student in Biomedicine, Clinical Trials Center Zurich, University Zurich, Switzerland

Apr 2018 – Nov 2018: Internship – Department of Internal Medicine & University Research Priority Program “Dynamics of Health and Aging”, University Hospital Zurich, Switzerland

2014–2018: Bachelor Student in Biology, University Zurich, Switzerland

Area of Research

The main focus is on empirical mixed methods research of randomised controlled trials, especially on various types of trial discontinuation, patient recruitment, resource use and costs, subgroup analysis, loss to follow-up, patient reported outcomes and protocol reporting. We are developing tools for better recruitment prediction, budget planning and judging the credibility of subgroup effects. In addition, we are conducting various types of systematic reviews and meta-analyses (aggregate data, individual patient data, network) in the fields of respiratory diseases and intensive care.

Collaborations

National Collaborations

  • Cochrane Switzerland (Dr. Erik von Elm), Institute for Social & Preventive Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne
  • Swiss Group for Clinical Cancer Research (SAKK) (Dr. Peter Brauchli), Bern
  • swissethics (Prof Susanne Driessen, Dr. Pietro Gervasoni), umbrella organisation of Swiss ethics committees, Bern
  • Swiss Clinical Trial Organisation (SCTO) (Prof Christiane Pauli-Magnus, Dr. Annette Magnin, Dr. Andri Christen), umbrella organisation of Swiss clinical trial units
  • Swiss Federal Office of Public Health, Division Research with Humans (Dr. Brigitte Meier, Dr. Matthias Rinderknecht), Bern
  • Institute for Bio- and Medical Ethics (Prof Bernice Elger), Basel
  • Epidemiology, Biostatistics and Prevention Institute (Prof Matthias Schwenkglenks, Prof Milo Puhan), University of Zurich
  • Service d'épidémiologie clinique (PD Dr. Thomas Agoritsas), University Hospital Geneva
  • Médecine nucléaire et imagerie moléculaire (Prof Martin Walter), University Hospital Geneva
  • Clinic for Neonatology (Prof Dirk Bassler), University Hospital Zurich
  • Department of Medicine (Prof Philipp Schuetz), Cantonal Hospital Aarau
  • Department of Nursing Sciences, INSPIRE project (Prof Sabina de Geest), University of Basel
  • Swiss Tropical and Public Health Institute (Prof Nino Künzli, Prof Christian Lengeler, PD Dr. Christian Schindler), University of Basel

International Collaborations

  • Department of Health Research Methods, Evidence, and Impact (HEI) (Prof Gordon Guyatt, Prof Holger Schünemann, Prof Stephen Walter, Prof Jason Busse, Prof John You, Prof Dominik Mertz, Prof Maureen Meade, Prof Deborah Cook), McMaster University, Hamilton, Canada
  • Department of Medical Biometry and Statistics (Prof Willi Sauerbrei), University Medical Center Freiburg, Germany
  • Cochrane Germany (PD Dr. Jörg Meerpohl, Dr. Anette Blümle), University Medical Center Freiburg, Germany
  • Trial Forge Initiative (Prof Shaun Treweek), Department of Health Services Research, University of Aberdeen, UK
  • Centre for Statistics in Medicine (Prof Sally Hopewell), University of Oxford, UK
  • Cardiovascular Epidemiology Unit (Prof Ignacio Ferreira Gonzalez), Vall d'Hebron Hospital, University of Barcelona, Spain
  • Knowledge and Evaluation Research Unit (Prof Victor Montori, Prof Hassan Murad), Mayo Clinic Rochester, USA
  • Clinical Research Institute (Prof Elie Akl), American University of Beirut, Lebanon
  • Department of Medicine (Prof Francois Lamontagne), University of Sherbrooke, Canada
  • Meta-Research Innovation Center at Stanford (METRICS) (Prof John Ioannidis), University of Stanford, USA
  • Centre for Evidence-based Practice (Prof Hans Lund), Western Norway University of Applied Sciences, Bergen, Norway
  • QUEST Center (Prof Daniel Strech), Berlin Institute of Health, Berlin, Germany
  • Department of Community Health and Epidemiology (Prof Bradley Johnston), Dalhousie University, Halifax, Canada
  • Chinese Evidence-based Medicine Center (Prof Xin Sun), West China Hospital, Sichuan University, Chengdu, China
  • Department of Statistics (Prof Byron Gajewski), University of Kansas Medical Center, Kansas City, USA
  • GRADE Working Group (subdivision health equity in guideline development, Prof Vivian Welch)

Forschungsgruppe PD Dr. Lars G. Hemkens

PD Dr. med. Lars G. Hemkens

Position(s) Senior Scientist Clinical Epidemiology

Institution University Hospital Basel

Phone +41 61 328 54 04

Email lars.hemkens@usb.ch

Name Funktion Arbeitsbereich
PD Dr. med. Lars G. Hemkens, MPH Leitung Klinische Epidemiologie

📷 Research Focus

  • Evidence-based health care
  • Comparative Effectiveness Research / HTA / Systematic Reviewing / Meta-Analyses
  • Routinely collected health data
  • Meta-epidemiology

🔖 Curriculum Vitae

  • 2012 to present: Senior Scientist, Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Basel, Switzerland
  • 2011 – 2012: Visiting Scholar and Harkness/Bosch Fellow in Health Care Policy and Practice, Stanford Prevention Research Center (Department of Medicine), Stanford University, CA, USA
  • 2009 – 2012: Research fellow, IQWiG – Institute for Quality and Efficiency in Health Care (Department of the Director), Cologne, Germany
  • 2004 – 2009: Physician / Research fellow, DIeM – Institute for Evidence-Based Medicine, Cologne, Germany
  • 2003 – 2004: Physician, St. Franziskus Hospital (Department of Internal Medicine), Cologne, Germany
  • 1994 – 2002: Medical School, Philipps University Marburg, Germany
Perrine Janiaud, PhD Research Fellow Klinische Epidemiologie

📷 Research Focus

  • Clinical trial methodology
  • Pragmatic randomized clinical trials
  • Systematic reviews and meta-analyzes
  • Meta-research

🔖 Curriculum Vitae

  • July 2020- Present: Scientist, Basel Institute for Clinical Epidemiology and Biostatistics, Switzerland
  • Aug 2017 – June 2020: Postdoctoral fellow, Meta-Research Innovation Center at Stanford (METRICS), Stanford University, California, USA
  • 2014-2017: PhD in Clinical Epidemiology, Claude Bernard University Lyon 1, France
  • 2011-2013: Master in Clinical Evaluation, Claude Bernard University Lyon 1, France
Julian Hirt, MSc Research Fellow Klinische Epidemiologie

📷 Research Focus

  • Exploring the evidence generation for COVID 19 (COVID-evidence)
  • Dementia care research
  • Nursing research
  • Systematic review methods

🔖 Curriculum Vitae


  • Since 2021: Research Associate, Basel Institute for Clinical Epidemiology and Biostatistics, Switzerland
  • Since 2018: International Graduate Academy (PhD studies), Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
  • Since 2017: Research Associate, Eastern Switzerland University of Applied Sciences, Switzerland
  • 2015 – 2017: Health and Nursing Sciences (MSc), Martin Luther University Halle-Wittenberg, Halle (Saale), Germany

Area of Research

Evidence-based health care, Comparative Effectiveness Research / HTA / Systematic Reviewing / Meta-Analyses, routinely collected health data, Meta-epidemiology

Forschungsgruppe PD Dr. Salome Dell-Kuster

PD Dr. med. Salome Dell-Kuster MSc Med Stats

Position(s) Senior consultant Anaesthesiology, Senior Researcher and Research Group Leader

Institution University Hospital Basel

Phone +41 61 32864 74

Email salome.dell-kuster@usb.ch

Name Funktion Arbeitsbereich
PD Dr. med. Salome Dell-Kuster, MSc Leitung Biostatistik

📷 Research Focus

  • Research group leader 'Perioperative patient safety'
  • Applied statistical methods to the field of anaesthesiology, intensive care medicine and surgery

🔖 Curriculum Vitae

  • 2017: Habilitation (venia docendi) on ‘Perioperative patient safety’
  • 2012 to present: Senior researcher and biostatistician, Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Switzerland
  • 2012 to present: Consultant, Department of Anaesthesiology, University Hospital Basel
  • 2008 - 2012: Junior researcher and biostatistician, Basel Institute for Clinical Epidemiology & Biostatistics, University Hospital Basel, Switzerland
  • 2006 - 2007: Master of Science in Medical Statistics, London School of Hygiene and Tropical Medicine, UK
  • 2004 - 2011: Resident, Department of Anaesthesiology, University Hospital Basel (including board-certification in anaesthesiology)
  • 2000 - 2003: Resident, Internal Medicine, Surgery & Anaesthesiology, Cantonal Hospital of Solothurn, Solothurn, Switzerland
  • 1993 - 1999: School of Medicine, University of Basel and Lausanne, Switzerland

Area of Research

Perioperative patient safety: (1) the clinician’s perspective in regards of bleeding, drug safety and intraoperative complications, (2) the patients’ perspective on the quality of perioerative care, and (3) key methodological aspects to consider as researcher; Validity and practicability of a classification system for intraoperative complications CLASSIC

Collaborations

National Collaborations

  • Prof. Dr. med. Georges Savoldelli, Department of Anaesthesiology, University Hospital Geneva
  • Prof. Dr. med. Eduardo Schiffer, Department of Anaesthesiology, University Hospital Geneva
  • Dr. med. Christoph Burkhart, Cantonal Hospital Graubünden
  • Prof. Dr. med. Pierre-Alain Clavien, Department of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland

International Collaborations

  • Prof. Dr. med. Harry van Goor, PhD, Department of Surgery, Radboud university medical centre, Nijmegen, the Netherlands
  • Prof. Dr. med. Ben Loveday, PhD, Department of Surgery, University of Auckland, New Zealand
  • Prof. Dr. med. Alexander Engel, Department of Surgery, University of Sydney, Royal North Shore Hospital, Sydney, Australia
  • Dr. med. Sonja Meier, Department of Anaesthesiology, Guy’s and St. Thomas’ Hospital, London, United Kingdom

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