Investigation of continuous effect modifiers in a meta-analysis on higher versus lower positive end-expiratory pressure (PEEP) in ventilated patients with acute respiratory distress syndrome (ARDS)

Briel M, Kasenda B, Lamontagne F, Meade M

Status: Abgeschlossen Dauer: Juni 2010 - Juli 2016

We will use the multivariable fractional polymonia interaction (MFPI) approach to investigate the interaction between continous patient baseline characteristics (body mass index, Pa02/Fi02, respiratory compliance, and oxygenation index) and the allocated ventilation strategy (higher versus lower PEEP). Outcomes of interest are in-hospital mortalitiy (up to 60 days), time to death, time to unassisted breathing, and incidence of pneumothorax. Our intention-to-treat population consists of all patients randomly assigned to a higher or lower PEEP strategy upon initiation of the protocol. For each study MFPI provides a continous treatmet effect function. The function of each of the three studies will be averaged by a novel (new) meta-analysis approach.

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