Stopped trials early for benefit – trials published after a stopped trial – ethical? (STOP-IT 3)

Matthias Briel, Hassan Murad, Gordon Guyatt

Status: Abgeschlossen Dauer: Nov. 2009 - Okt. 2016

The study investigates how often randomised trials (RCTs) are launched or completed after the publication of a trial stopped early for benefit addressing the same question. RCTs are stopped early for benefit because it is considered unethical to deprive patients in control groups from an intervention of obvious benefit. If new RCTs on the same research question are launched following the publication of trial stopped early for benefit the current practice in terms of stopping RCTs for apparent benefit might be considered as not sufficiently conservative. The project investigates the prevalence of this perception in the research community.

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